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The FDA approved the immune checkpoint inhibitors pembrolizumab and nivolumab for remedy of recurrent or metastatic HNSCC and pembrolizumab as main therapy for unresectable illness. Therapy is usually multimodal, consisting of surgical procedure followed by chemoradiotherapy (CRT) for oral cavity cancers and primary CRT for pharynx and larynx cancers. Conventional staging of HNSCC utilizing the tumour–node–metastasis system has been supplemented by the 2017 AJCC/UICC staging system, which includes extra info relevant to HPV-positive disease. An Author Correction to this text was revealed on 19 January 2023
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